Hepatic

Definition

Hepatic refers to anything relating to the liver, the largest internal organ and a critical site of metabolism, detoxification, synthesis of plasma proteins (albumin, clotting factors), bile production, and storage of glycogen, vitamins, and iron.

Common Hepatic Conditions

• Hepatitis (viral, alcoholic, drug-induced)
• Cirrhosis
• Liver cancer
• Fatty liver disease (NAFLD/NASH)
• Hepatic encephalopathy
• Liver failure

Hepatic Function Tests

AST, ALT (hepatocellular injury); alkaline phosphatase, GGT, bilirubin (cholestatic); albumin, PT/INR (synthetic function); ammonia (encephalopathy).

Nursing Considerations

Assess for hepatic dysfunction: jaundice, ascites, asterixis, bruising, edema (review medications). Many require dose adjustment in liver disease. Avoid acetaminophen and other hepatotoxic drugs. Provide nutritional support.

NCLEX Relevance

Liver disease affects medication metabolism and clotting.